Structural insight into the substrate- and dioxygen-binding manner in the catalytic cycle of rieske nonheme iron oxygenase system, carbazole 1,9a-dioxygenase

Table 2 Substrate-binding statuses in each subunit of Oxy in the catalytic cycle

State^a	Oxy subunits
State^a	Chain A	Chain B	Chain C
(1) Resting (Oxy: Fd^rest)	-	-	-
(2) Reduced (Oxy: Fd^red)	-	-	-
(2’) CAR-bound (Oxy: Fd^CAR)	-	CAR	CAR
(3) Reduced CAR-bound (Oxy: Fd^red-CAR)	-	CAR	CAR
(3’) Oxygen-bound (Oxy: Fd^O2)	Peroxide (end-on)	Peroxide (end-on)	Peroxide (end-on)
(4) CAR- and oxygen-bound (Oxy: Fd^CAR-O2)	Peroxide (end-on)	Peroxide (side-on)	Peroxide (side-on)
		+CAR	+CAR

ISSN: 1472-6807