Table 1 Positions of the cytokine-receptor binding sites in known structures of ternary and binary complexes.
From: A model of the ternary complex of interleukin-10 with its soluble receptors
Cytokine-receptor complexes (PDB code/reference) | Site I (Ligand/Receptor) | Site II (Ligand/Receptor) | Site III (Recept/Recept) | ||
|---|---|---|---|---|---|
| Â | SSE* Ligand | SSE* Receptor | SSE* Ligand | SSE* Receptor | Contacting Domains |
Ternary complexes | Â | Â | Â | Â | Â |
hGH/GHbp/GHbp (3HHR [23]) | A, loop AB, D | L1, L3-L6 | A, C | L1, L3-L6 | D2-D2 |
hEPO/sEPOR/sEPOR (1EER [24]) | A, loop AB, D | L1-L6 | A, C | L1-L3, L5, L6 | no interaction |
oPL/srPRLR/srPRLR (1F6F [25]) | A, loop AB, D | L1-L6 | A, C | L1-L4 | D2-D2 |
hIL6/sIL6Rα /gp130 (D1-D3) (1P9M [29]) | A, D | L2-L6 | A, C | L1-L3, L5 | D2-D3 |
Binary complexes | Â | Â | Â | Â | Â |
hINF-γ /sINF-γ Rα ** (1FG9 [53]) | A, loop AB, F' | L2, L3, L5, L6 |  |  |  |
hLIF/gp130 (D2-D3) (1PVH [54]) | Â | Â | A, C | L2, L3, L5 | Â |
G-CSF/G-CSFR (BN-BC) (1CD9 [27]) | Â | Â | A, C | L2-L6 | Â |
hIL4/IL4-R1 (1IAR [26]) | Â | Â | A, C | L1-L6 | Â |
hIL-10/sIL-10R1** (1J7V [22]) | A, loop AB, F' | L2-L6 | Â | Â | Â |
cmvIL-10/sIL-10R1** (1LQS [55]) | A, loop AB, F' | L2-L6 | Â | Â | Â |
vIL-6/gp130 (1I1R [56]) | Â | Â | A, C | L2, L3, L5 | Â |
Ternary hIL-10 complex | Â | Â | Â | Â | Â |
hIL10/sIL10R1/sIL10R2**,*** | A, loop AB, F' | L2-L6 | A, D | L2, L3, L5, L6 | D2-D2 |