Table 2 Hydrophobic patches of IL-10, sIL-10R1 and sIL-10R2
From: A model of the ternary complex of interleukin-10 with its soluble receptors
IL-10 | Interaction site | |
|---|---|---|
Patch 1 Residue Access. (%) | Surface area 189 Å 2 L46 L53 I145 A152 50 25 34 44 | IL-10/sIL-10R1 interface, with patch 3 of sIL-10R1 |
Patch 2 Residue Access. (%) | Surface area 294 Å 2 H14 P16 P20 I158 73 66 71 25 | IL-10/sIL10R1 interface, with patch 6 of sIL-10R1 IL-10/sIL10R2 interface, with Patch 7 of sIL-10R2 |
Patch 3 Residue Access. (%) | Surface area 183 Å 2 F36 A89 H90 33 86 45 | IL-10/sIL-10R2 interface with Patch 2 (sIL-10R2) |
IL-10R1 Domain D1 | ||
Patch 1 Residue Access. (%) | Surface area 475 Å 2 I51 Y60 A64 V65 L67 18 39 90 34 46 M129 P131 A132 60 38 100 | No interaction |
Patch 2 Residue Access. (%) | Surface area 448 Å 2 P6 P9 W12 T25 P26 P28 L58 45 45 45 39 56 65 56 | No interaction |
Patch 3 Residue Access. (%) | Surface area 207 Å 2 Y43 G44 I45 44 66 83 | IL-10/sIL10R1 interface, with patch 1 of IL-10 |
Domain D2 | ||
Patch 4 Residue Access. (%) | Surface area 546 Å 2 I113 H114 G116 F117 60 56 47 58 L119 L172 G175 V177 41 84 61 69 | sIL-10R1/sIL10R2 interface, with patch 5 of sIL-10R2 |
Patch 5 Residue Access. (%) | Surface area 409 Å 2 V153 P154 G155 F157 F159 H161 45 56 55 73 43 56 | sIL-10R1/sIL10R2 interface, with patch 6 of sIL-10R2 |
Patch 6 Residue Access. (%) | Surface area 253 Å 2 H142 F143 A189 77 62 35 | IL-10/sIL10R1 interface, with patch 2 of IL-10 |
IL-10R2 Domain D1 | ||
Patch 1 Residue Access. (%) | Surface area 635 Å 2 L2 G3 M4 P6 P7 A28 77 78 45 56 40 91 F29 G32 F83 A84 97 93 34 85 | No interaction |
Patch 2 Residue Access. (%) | Surface area 284 Å 2 L41 I47 F48 29 88 62 | IL-10/sIL10R2 interface, with patch 3 of IL-10 |
Patch 3 Residue Access. (%) | Surface area 154 Å 2 C98 P98A V99 52 48 42 | No interaction |
Domain D2 | ||
Patch 4 Residue Access. (%) | Surface area 572 Å 2 F160 I162 F169 L172 73 26 12 71 L175 P176A W177 49 73 57 | No interaction |
Patch 5 Residue Access. (%) | Surface area 274 Å 2 V113 L114 A115 H119 47 62 100 40 | sIL-10R1/sIL10R2 interface, with patch 4 of sIL-10R1 |
Patch 6 Residue Access. (%) | Surface area 203 Å 2 P107 L123 A124 69 65 54 | sIL-10R1/sIL10R2 interface, with patch 5 of sIL-10R1 |
Patch 7 Residue Access. (%) | Surface area 178 Å 2 W143 P189 57 48 | IL-10/sIL10R2 interface, with patch 2 of IL-10 |