Table 3 Intermolecular hydrogen bonds of the IL10/sIL10R1/sIL10R2 complex

IL-10

SSE

IL-10R1

SSE

Distance Å

R24L NE

A

R191R O

L6

3.0

R24L NH1

A

V188R O

L6

2.9

R24L NH1

A

R191R O

L6

3.0

R27L NE

A

S190R O

L6

2.9

R27L NH1

A

D100R OD2

L4

3.2

K34L NZ

A

D100R OD1

L4

2.9

Q38L OE1

A

R96R N

L4

3.0

D41L O

loop AB

R76R NH1

L3

2.9

Q42L O

loop AB

R76R NH2

L3

3.0

D44L OD1

loop AB

R76R NH2

L3

2.8

D44L O

loop AB

G44R N

L2

2.9

N45L N

loop AB

E46R OE2

L2

3.0

K138S NZ

F'

Y43R OH

L2

2.8

S141S O

F'

R96R NH2

L4

2.9

D144S OD1

F'

R96R NH2

L4

2.8

D144S OD2

F'

R96R NH2

L4

3.0

E151S OE1

F'

R191R NH1

L6

2.9

E151S OE2

F'

R191R NH1

L6

2.8

E151S OE1

F'

R191R NH2

L6

2.9

IL-10-IL-10R2 interface

N18L OD1

A

R191A NH1

L6

2.7

N18L ND2

A

S142A OG1

L6

2.7

N21L ND2

A

N138A O

α A

2.8

R24L NH2

A

N138A OD1

α A

2.7

R24L NH2

A

T133A O

loop Bα A

3.1

D28L OD1

A

K69A NZ

L3

2.8

D28L OD2

A

K69A NZ

L3

3.0

D28L O

A

K69A NZ

L3

3.2

R32L NH1

A

S68A OG

L3

3.3

E81L OE2

loop CD

R46A NH2

L2

3.3

N92L OD1

D

R46A NH1

L2

2.8

IL-10R1-IL-10R2 interface

E145R OE1

C

N138A OD1

L5

3.2

E145R OE2

C

N141A ND2

L5

2.7

E147R OE2

C

K126A NZ

loop Bα A

3.2

H161R NE2

C'

A124A O

loop Bα A

2.9

K162R NZ

C'

Q110A OE1

A

2.6

K165R NZ

loop C'E

N141A OD1

L5

2.7

H166R NE2

loop C'E

Y166A OH

loop C'E

3.0

S170R OG

E

R121A NH1

B

3.1

S170R O

E

R121A NH1

B

2.6

K185R NZ

F

E132A OE2

loop Bα A

3.2