Table 3 Comparison of predicted and experimental changes in aggregation for IAPP variants, relative to the corresponding human IAPP sequence.
From: Prediction of "hot spots" of aggregation in disease-linked polypeptides
Variant | ΔAP* | Observed aggregation‡ |
|---|---|---|
(20–29) Cat | -5.12 | = |
(20–29) Rat | -16.46 | - |
(20–29) Hamster | -32.73 | - |
R18H | +0.94 | + |
L23F | +1.70 | + |
V26I | +0.42 | + |
R18H+L23F+V26I | +3.06 | + |
(22–27) N22A | +31.53 | + |
(22–27) F23A | -42.96 | - |
(22–27) G24A | +11.96 | + |
(22–27) I26A | -44.5872 | - |
(22–27) L27A | -33.99 | - |
S20G | -1.09 | + |
ProIAPP | +31.40 | +? |