Figure 4

Secondary structure and sequence of Lm MK. Invariant or well-conserved residues are boxed in red, orange and lime. Red signifies residues conserved in the three trypanosomatid, Rn MK and Mj MK sequences, orange residues conserved in any four out of the five sequences, green those conserved in the parasite enzymes. Residues involved in substrate binding are marked with cyan dots and the catalytic aspartate and lysine residues with green stars. The secondary structural elements, as shown in part A, are given above the sequence. Three highly conserved GHMP motifs are marked.