From: Spectrum of disease-causing mutations in protein secondary structures
Amino acid group | Original residues | Expected residues | χ2 | P value | Mutant residues | Expected residues | χ2 | P value |
---|---|---|---|---|---|---|---|---|
Hydrophobic | 355 | 348 | 0.13 | 7.19E-01 | 320 | 322 | 0.01 | 9.13E-01 |
Positively charged | 95 | 140 | 14.36*** | 1.51E-04 | 85 | 71 | 2.75 | 9.71E-02 |
Negatively charged | 196 | 147 | 16.56*** | 4.71E-05 | 166 | 152 | 1.39 | 2.39E-01 |
Conformational | 77 | 54 | 9.96** | 1.60E-03 | 136 | 111 | 5.50* | 1.90E-02 |
Polar | 86 | 118 | 8.70** | 3.17E-03 | 137 | 159 | 2.94 | 8.62E-02 |
A+T | 119 | 121 | 0.04 | 8.34E-01 | 84 | 114 | 7.73** | 5.44E-03 |
Sum | 928 | 928 | Â | Â | 928 | 928 | Â | Â |