Figure 1

Comparison of the CASP6 results of the Kolinski-Bujnicki group with post-CASP contact-based modeling. Results of the contact-based ranking of Kolinski-Bujnicki's models from CASP6 is shown in (a). The scoring function was based on the contact data set from the best two predictors (Baker and PROFcon). The accuracy of the contact data used for scoring 5 models of each target is plotted against the RMSD of the model ranked as first in CASP6 by the Kolinski-Bujnicki group (green squares) and against the RMSD of the protein model ranked as first by the contact-based scoring function (red lines which join corresponding points). Results for NF and FR/A categories are presented separately. The most significant improvement is observed in the case of FR/A targets with the accuracy of the contact prediction range of 15–30%. In a similar way the results of the refinement simulations are presented in the right-hand panels (b). The refinement simulations performed better than the post-simulation ranking of the models.