Figure 12

Clustering of 116 non-redundant ATP binding sites based on their surface similarity. The dendrogram represents the results of complete-linkage clustering, applied to SurfaceScreen score between all surfaces in our dataset (a). Each node is color-coded representing its biological functions as assessed through EC numbers or literature references. A second grayscale-coded shape can be found on all node edges that corresponds to the ATP conformations in Figure 9. A representative binding surface from each cluster is shown in (b).