Fast dynamics perturbation analysis for prediction of protein functional sites

BMC Structural Biology

Table 1 Performance statistics for Fast DPA and original DPA using a threshold of 0.96

	Rank-1 Predictions^a	Any match^b	Recall ≥ 0.3^c	Precision ≥ 0.3^d	Recall ≥ 0.5^c	Precision ≥ 0.5^d
Original	287	0.87	0.80	0.68	0.76	0.44
Fast	267	0.94	0.86	0.65	0.75	0.38

^a Number of proteins for which at least one DPA cluster was produced, out of 305 total.
^b Fraction of rank-1 predictions that have at least one overlapping residue with the binding site.
^c Fraction of binding sites for which the recall was at least 0.3 or 0.5.
^d Fraction of predictions for which the precision was at least 0.3 or 0.5.

ISSN: 1472-6807