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Table 1 Number of over-exposed residues with their exposed surface area (ASA) greater than the Ala-X-Ala extended state ASA (ESA).

From: Context dependent reference states of solvent accessibility derived from native protein structures and assessed by predictability analysis

Res.

Freq

(%)

Res.

Freq

(%)

Res.

Freq

(%)

Res.

Freq

(%)

A

0.66

G

2.35

M

0.36

S

1.91

C

0.10

H

0.62

N

3.31

T

0.94

D

3.45

I

0.05

P

0.45

V

0.15

E

2.54

K

0.76

Q

1.22

W

0.11

F

0.15

L

0.09

R

0.88

Y

0.20

  1. Typically, polar and charged residues have a significant number of such cases.