Figure 6

Highly conserved regions within the ASP1 trimer. (A) Conserved residues important for forming the central pore and elbow regions. A circle delineates each region. Absolutely conserved residues are colored in purple and highly conserved ones are colored in yellow. (B) and (C) Stereo views of the central pore region and C-terminal elbow regions, respectively. Conserved residues are indicated as in (A). Magnesium ions are shown as black spheres with their first hydration shell of water molecules shown as red spheres.