Figure 5
From: Computational re-engineering of Amylin sequence with reduced amyloidogenic potential
δ rmsd and RMSF plots for mutants L12E, A8E, and G33E over a 20ns simulation. The top figures display δ rmsd graphs between each mutant and the native Amylin, and the bottom plots are the RMSF plots. (a) Mutant L12E shows a δ rmsd <1.2 and an RMSF <0.6 at residue 12, (b) mutant A8E exhibits a δ rmsd <1.1 and RMSF <0.5 at residue 8, and (c) mutant G33E has a δ rmsd <1 and an RMSF <1 at residue 33. δ rmsd and RMSF results show extremely small modifications in structure and minimal structural variance at the amino acid mutation sites.