Fig. 3From: Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand a Collapsed binding mode of agonist BIO592 in the hydrophobic LBS of RORγ. b Benzoxazinone ring system of agonist BIO592 packing against His479 of RORγ stabilizing agonist conformation of the AF2 helixBack to article page