Taylor, Stoye and Taylor applied protein structure comparison methods to resolve the ambiguous relationship between Spumaretrovirinae (foamy viruses) and the Orthoretrovirinae (e.g. HIV). Their results show the relationship conforms to a simple linear correspondence, with similarities suggesting the viral capsids originated from a common ancestor with a double domain structure.
The comparison methodology used in this article demonstrates an effective general approach to problems where the components have a high intrinsic level of similarity.
BMC Structural Biology is an open access, peer-reviewed journal that considers articles on investigations into the structure of biological macromolecules, including solving structures, structural and functional analyses, and computational modeling.