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  1. Content type: Research article

    One of the main concerns of the modern medicine is the frightening spread of antimicrobial resistance caused mainly by the misuse of antibiotics. The researchers worldwide are actively involved in the search f...

    Authors: Anna Verdino, Felicia Zollo, Margherita De Rosa, Annunziata Soriente, Miguel Ángel Hernández-Martínez and Anna Marabotti

    Citation: BMC Structural Biology 2018 18:13

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  2. Content type: Methodology article

    Dramatic progress has recently been made in cryo-electron microscopy technologies, which now make possible the reconstruction of a growing number of biomolecular structures to near-atomic resolution. However, ...

    Authors: Julio A. Kovacs, Vitold E. Galkin and Willy Wriggers

    Citation: BMC Structural Biology 2018 18:12

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  3. Content type: Research article

    Eukaryotic translation initiation factor 1A (eIF1A) is universally conserved in all organisms. It has multiple functions in translation initiation, including assembly of the ribosomal pre-initiation complexes,...

    Authors: Jielin Yu and Assen Marintchev

    Citation: BMC Structural Biology 2018 18:11

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  4. Content type: Research article

    Lysozyme purified from duck eggs (DEL) has long been used as a model antigen as a counterpoint to the enzyme purified from hen eggs (HEL). However, unlike the single C-type variant found in hen eggs, duck eggs...

    Authors: David B. Langley and Daniel Christ

    Citation: BMC Structural Biology 2018 18:10

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  5. Content type: Research article

    Amyloidogenic proteins are most often associated with neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, but there are more than two dozen human proteins kno...

    Authors: Jeddidiah W. D. Griffin and Patrick C. Bradshaw

    Citation: BMC Structural Biology 2018 18:9

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  6. Content type: Research article

    Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-sp...

    Authors: Saara Laulumaa, Tuomo Nieminen, Arne Raasakka, Oda C. Krokengen, Anushik Safaryan, Erik I. Hallin, Guillaume Brysbaert, Marc F. Lensink, Salla Ruskamo, Ilpo Vattulainen and Petri Kursula

    Citation: BMC Structural Biology 2018 18:8

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  7. Content type: Research article

    Syphilis continues to be a major global health threat with 11 million new infections each year, and a global burden of 36 million cases. The causative agent of syphilis, Treponema pallidum subspecies pallidum, is...

    Authors: Simon Houston, Karen Vivien Lithgow, Kara Krista Osbak, Chris Richard Kenyon and Caroline E. Cameron

    Citation: BMC Structural Biology 2018 18:7

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  8. Content type: Research article

    Due to dengue virus disease, half of the world population is at severe health risk. Viral encoded NS2B-NS3 protease complex causes cleavage in the nonstructural region of the viral polyprotein. The cleavage is...

    Authors: Muhammad Waseem Sarwar, Adeel Riaz, Syed Muhammad Raihan Dilshad, Ahmed Al-Qahtani, Muhammad Shah Nawaz-Ul-Rehman and Muhammad Mubin

    Citation: BMC Structural Biology 2018 18:6

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  9. Content type: Research article

    Earlier based on bioinformatics analyses, we had predicted the Mycobacterium tuberculosis (M.tb) proteins; Rv1555 and Rv1554, among the potential new tuberculosis drug targets. According to the ‘TB-drugome’ the R...

    Authors: Pallabini Dash, M. Bala Divya, Lalitha Guruprasad and Kunchur Guruprasad

    Citation: BMC Structural Biology 2018 18:5

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  10. Content type: Correction

    After publication of the article [1], it has been brought to our attention that there is a discrepancy between the publication date on the pdf and online formats. The date on the pdf is 6th February 2018 and o...

    Authors: Nikolay A. Alemasov, Nikita V. Ivanisenko, Srinivasan Ramachandran and Vladimir A. Ivanisenko

    Citation: BMC Structural Biology 2018 18:3

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    The original article was published in BMC Structural Biology 2018 18:1

  11. Content type: Research Article

    Aquaporins (AQPs) facilitate the passage of small neutral polar molecules across membranes of the cell. In animals there are four distinct AQP subfamilies, whereof AQP8 homologues constitute one of the smalles...

    Authors: Andreas Kirscht, Yonathan Sonntag, Per Kjellbom and Urban Johanson

    Citation: BMC Structural Biology 2018 18:2

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  12. Content type: Research

    So far, little is known about the molecular mechanisms of amyotrophic lateral sclerosis onset and progression caused by SOD1 mutations. One of the hypotheses is based on SOD1 misfolding resulting from mutations a...

    Authors: Nikolay A. Alemasov, Nikita V. Ivanisenko, Srinivasan Ramachandran and Vladimir A. Ivanisenko

    Citation: BMC Structural Biology 2018 18(Suppl 1):1

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    This article is part of a Supplement: Volume 18 Supplement 1

    The Correction to this article has been published in BMC Structural Biology 2018 18:3

  13. Content type: Research Article

    The 5′-methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and polyamine metabolism and in the methionine salvage pathway, is considered as a potential drug target against cancer and trypano...

    Authors: Hela Abid, Emna Harigua-Souiai, Thouraya Mejri, Mourad Barhoumi and Ikram Guizani

    Citation: BMC Structural Biology 2017 17:9

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  14. Content type: Research Article

    Membrane proteins are difficult targets for structure prediction due to the limited structural data deposited in Protein Data Bank. Most computational methods for membrane protein structure prediction are base...

    Authors: Dorota Latek

    Citation: BMC Structural Biology 2017 17:8

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  15. Content type: Research Article

    The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. Some loss-of-function mutations of the TWIST1 gene have been shown to cause an autosomal dominant craniosyn...

    Authors: Charlotte Bouard, Raphael Terreux, Agnès Tissier, Laurent Jacqueroud, Arnaud Vigneron, Stéphane Ansieau, Alain Puisieux and Léa Payen

    Citation: BMC Structural Biology 2017 17:6

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  16. Content type: Research Article

    Formamidopyrimidine-DNA glycosylase (Fpg) removes abundant pre-mutagenic 8-oxoguanine (oxoG) bases from DNA through nucleophilic attack of its N-terminal proline at C1′ of the damaged nucleotide. Since oxoG ef...

    Authors: Alexander V. Popov, Anton V. Endutkin, Yuri N. Vorobjev and Dmitry O. Zharkov

    Citation: BMC Structural Biology 2017 17:5

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  17. Content type: Database

    More than 7000 papers related to “protein refolding” have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for...

    Authors: Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura and Kei Yura

    Citation: BMC Structural Biology 2017 17:4

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  18. Content type: Research Article

    The Spumaretrovirinae (foamy viruses) and the Orthoretrovirinae (e.g. HIV) share many similarities both in genome structure and the sequences of the core viral encoded proteins, such as the aspartyl protease and ...

    Authors: William R. Taylor, Jonathan P. Stoye and Ian A. Taylor

    Citation: BMC Structural Biology 2017 17:3

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  19. Content type: Methodology article

    T cell receptor (TCR) molecules are involved in the adaptive immune response as they distinguish between self- and foreign-peptides, presented in major histocompatibility complex molecules (pMHC). Former studi...

    Authors: Thomas Hoffmann, Antoine Marion and Iris Antes

    Citation: BMC Structural Biology 2017 17:2

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  20. Content type: Research article

    The post-translational modification pathway referred to as pupylation marks proteins for proteasomal degradation in Mycobacterium tuberculosis and other actinobacteria by covalently attaching the small protein Pu...

    Authors: Jonas Barandun, Fred F. Damberger, Cyrille L. Delley, Juerg Laederach, Frédéric H. T. Allain and Eilika Weber-Ban

    Citation: BMC Structural Biology 2017 17:1

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  21. Content type: Methodology article

    Post-crystallization dehydration methods, applying either vapor diffusion or humidity control devices, have been widely used to improve the diffraction quality of protein crystals. Despite the fact that RNA cr...

    Authors: HaJeung Park, Tuan Tran, Jun Hyuck Lee, Hyun Park and Matthew D. Disney

    Citation: BMC Structural Biology 2016 16:19

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  22. Content type: Methodology Article

    Synchrotron radiation facilities are pillars of modern structural biology. Small-Angle X-ray scattering performed at synchrotron sources is often used to characterize the shape of biological macromolecules. A ...

    Authors: Luca Costa, Alexander Andriatis, Martha Brennich, Jean-Marie Teulon, Shu-wen W. Chen, Jean-Luc Pellequer and Adam Round

    Citation: BMC Structural Biology 2016 16:18

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  23. Content type: Research article

    TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previousl...

    Authors: Luis Sanchez-Pulido, Laurent Perez, Steffen Kuhn, Isabelle Vernos and Miguel A. Andrade-Navarro

    Citation: BMC Structural Biology 2016 16:17

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  24. Content type: Research

    Currently, alternate plasticizers are used to replace phthalate plasticizers in children’s toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and law...

    Authors: Ishfaq A. Sheikh, Muhammad Yasir, Muhammad Abu-Elmagd, Tanveer A. Dar, Adel M. Abuzenadah, Ghazi A. Damanhouri, Mohammed Al-Qahtani and Mohd A. Beg

    Citation: BMC Structural Biology 2016 16(Suppl 1):15

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    This article is part of a Supplement: Volume 16 Supplement 1

  25. Content type: Research

    Di-(2-ethylhexyl)phthalate (DEHP) is a common endocrine disrupting compound (EDC) present in the environment as a result of industrial activity and leaching from polyvinyl products. DEHP is used as a plasticiz...

    Authors: Ishfaq A. Sheikh, Muhammad Abu-Elmagd, Rola F. Turki, Ghazi A. Damanhouri, Mohd A. Beg and Mohammed Al-Qahtani

    Citation: BMC Structural Biology 2016 16(Suppl 1):16

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    This article is part of a Supplement: Volume 16 Supplement 1

  26. Content type: Research article

    CASKIN2 is a neuronal signaling scaffolding protein comprised of multiple ankyrin repeats, two SAM domains, and one SH3 domain. The CASKIN2 SH3 domain for an NMR structural determination because its peptide-bi...

    Authors: Jamie J. Kwan and Logan W. Donaldson

    Citation: BMC Structural Biology 2016 16:14

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  27. Content type: Research article

    Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds...

    Authors: Sumit Handa, Blair G. Paul, Jeffery F. Miller, David L. Valentine and Partho Ghosh

    Citation: BMC Structural Biology 2016 16:13

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  28. Content type: Research article

    The Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) is only aspartyl aminopeptidase which is found in the genome of P. falciparum and is essential for its survival. The PfM18AAP enzyme performs vario...

    Authors: Madhulata Kumari, Subhash Chandra, Neeraj Tiwari and Naidu Subbarao

    Citation: BMC Structural Biology 2016 16:12

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  29. Content type: Research article

    We comprehensively analyzed X-ray cocrystal structures of dipeptidyl peptidase IV (DPP-4) and its inhibitor to clarify whether DPP-4 alters its general or partial structure according to the inhibitor used and ...

    Authors: Hiroyuki Nojima, Kazuhiko Kanou, Genki Terashi, Mayuko Takeda-Shitaka, Gaku Inoue, Koichiro Atsuda, Chihiro Itoh, Chie Iguchi and Hajime Matsubara

    Citation: BMC Structural Biology 2016 16:11

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  30. Content type: Research article

    This study investigates the allosteric coupling that exists between the intra- and extracellular parts of human β2-adrenergic receptor (β2-AR), in the presence of the intracellular loop 3 (ICL3), which is missing...

    Authors: Canan Ozgur, Pemra Doruker and E. Demet Akten

    Citation: BMC Structural Biology 2016 16:9

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  31. Content type: Research article

    During inflammation, leukocytes are captured by the selectin family of adhesion receptors lining blood vessels to facilitate exit from the bloodstream. E-selectin is upregulated on stimulated endothelial cells...

    Authors: Anne D. Rocheleau, Thong M. Cao, Tait Takitani and Michael R. King

    Citation: BMC Structural Biology 2016 16:10

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  32. Content type: Research article

    S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inf...

    Authors: Haili Lin, Gregers Rom Andersen and Laure Yatime

    Citation: BMC Structural Biology 2016 16:8

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  33. Content type: Research article

    The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis,...

    Authors: Douglas J. Marcotte, YuTing Liu, Kevin Little, John H. Jones, Noel A. Powell, Craig P. Wildes, Laura F. Silvian and Jayanth V. Chodaparambil

    Citation: BMC Structural Biology 2016 16:7

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  34. Content type: Research article

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Authors: Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    Citation: BMC Structural Biology 2016 16:5

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  35. Content type: Software

    The term ‘molecular cartography’ encompasses a family of computational methods for two-dimensional transformation of protein structures and analysis of their physicochemical properties. The underlying algorith...

    Authors: Dimitrios Georgios Kontopoulos, Dimitrios Vlachakis, Georgia Tsiliki and Sofia Kossida

    Citation: BMC Structural Biology 2016 16:4

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    The Publisher's Erratum to this article has been published in BMC Structural Biology 2016 16:6

  36. Content type: Research Article

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Authors: Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    Citation: BMC Structural Biology 2016 16:3

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  37. Content type: Research article

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Authors: Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    Citation: BMC Structural Biology 2016 16:1

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  38. Content type: Research article

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Authors: Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    Citation: BMC Structural Biology 2015 15:24

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  39. Content type: Research article

    Protein-protein interactions (PPIs) mediate the vast majority of biological processes, therefore, significant efforts have been directed to investigate PPIs to fully comprehend cellular functions. Predicting c...

    Authors: Surabhi Maheshwari and Michal Brylinski

    Citation: BMC Structural Biology 2015 15:23

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  40. Content type: Research article

    Many β-strands are not flat but bend and/or twist. However, although almost all β-strands have a twist, not all have a bend, suggesting that the underlying force(s) driving β-strand bending is distinct from th...

    Authors: Kazuo Fujiwara, Shinichi Ebisawa, Yuka Watanabe, Hiromi Fujiwara and Masamichi Ikeguchi

    Citation: BMC Structural Biology 2015 15:21

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  41. Content type: Research article

    RNA ligases 2 are scarce and scattered across the tree of life. Two members of this family are well studied: the mitochondrial RNA editing ligase from the parasitic trypanosomes (Kinetoplastea), a promising dr...

    Authors: Sandrine Moreira, Emmanuel Noutahi, Guillaume Lamoureux and Gertraud Burger

    Citation: BMC Structural Biology 2015 15:20

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  42. Content type: Research article

    Stimulation of phospholipase Cβ (PLCβ) by the activated α-subunit of Gq (Gαq) constitutes a major signaling pathway for cellular regulation, and structural studies have recently revealed the molecular interaction...

    Authors: Dawna HT Kwan, Ka M. Wong, Anthony SL Chan, Lisa Y. Yung and Yung H. Wong

    Citation: BMC Structural Biology 2015 15:18

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  43. Content type: Research article

    The c-Jun N-terminal kinases (JNKs), members of the mitogen-activated protein kinase (MAPK) family, engage in diverse cellular responses to signals produced under normal development and stress conditions. In Dros...

    Authors: Sarin Chimnaronk, Jatuporn Sitthiroongruang, Kanokporn Srisucharitpanit, Monrudee Srisaisup, Albert J. Ketterman and Panadda Boonserm

    Citation: BMC Structural Biology 2015 15:17

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2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)

    Usage 
    191,858 downloads


    Social Media Impact
    17 mentions

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