Figure 2

Pictorial representation of the interface residues of A chain of E glycoprotein 2a, 2b and 2c. Heterodimeric interfaces of A chain Shown here are the interactions between A chain of E glycoprotein (in blue) and D chain of M protein (in cyan); the interface residues on A chain are shown in red as spheres, Panel a shows the interface in immature virus at neutral pH (structure 3C6D), Panel b shows interface in immature virus at low pH (structure 3C6R) while Panel c shows the interface of mature virus (structure 1P58). Three domains in A chain are labeled as DI, DII and DIII. For comparison sake the three structures were superposed with respect to chain A using Dalilite programme [26, 27]. 2 d, 2e and 2f: Homodimeric interface of A chain Shown here are the interactions between A chain (in blue) and B chain(in pink) of E glycoprotein. The panel arrangement and domain labels are the same as mentioned above in case of 2a, b and c. Interface residues on A chain, participating in homodimeric interface are shown in green color as spheres. The three structures being compared here were superimposed with respect to chain B using Dalilite programme as mentioned above. 2g: Interface residues of A chain in mature virus (structure 1P58) The residues on A chain (in green) of E glycoprotein interacting with C chain (in cyan) are shown in pink as spheres. The three domains of chain A are labeled as DI, DII and DIII as mentioned above.