Table 1 Inhibition of cathepsins B and L by cystatins.a
From: Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling
Cystatin | K i | |
|---|---|---|
Cathepsin B | Cathepsin L | |
Oryzacystatin-1 | 78.5 nM | 0.73 nM |
Canecystatin-1 | 87.6 nM | 0.10 nM |
Canecystatin-4b | 0.58 nM | 0.0035 nM |
Oryzacystatin-1 N-terminal deletion (NΔ) | NI | 5.66 nM |
Clone A10 | 11.2 nM | 1.63 nM |
Reverse Mutant 1 (T30I) | NI | 1.93 nM |
Reverse Mutant 2 (Q97L) | NI | 11.7 nM |
Reverse Mutant 3 (T30I, Q97L) | NI | 12.5 nM |