Figure 3

Determination of the potential TMD center of NMR-structures in the membrane. According to the statistical results from the PepLook scan runs for GpA (A), EphA1 (B) and Erb2 (C), we show the average percentage of helical structure in all the structures obtained with a window of 19 a.a. (red line). The blue line represents the average of the ratio of hydrophobic to the hydrophilic accessible surface (ASAr) for 19 a.a. long peptides with a window of 5. The orange line represents the depth of the average penetration into the membrane from 10 to -10 Å of the 19 a.a. long peptides with a window of 3. The amino acid on the × axis represents the center of the considered scan-peptides. TMD centers, determined by the Impala[18] and OPM methods[20] with NMR structures, are indicated by a box for each monomer considered.