Figure 2

Characteristics of different types of interfaces. The three kinds of interfaces are pre-made (blue color), induced-fit (brown) and others (green). A). A plot of Cα RMSD for the pair of interacting partners is shown. Completely pre-made interfaces are enclosed in a yellow square. B). The extent of conformational change for the three kinds of interfaces is shown. The graphs plot only the majority of the points (Cα RMSD ≤6 Å) for the sake of clarity. This figure illustrates that A). Pre-made interfaces largely bind to induced-fit interfaces, and B). Although pre-made interfaces show small magnitude of structural change, the extent of conformational change they undergo is comparable to that observed in induced-fit/other interfaces. For both sets, points corresponding to complexes solved at a resolution >2.5 Å are encircled.