Skip to main content

Table 4 Results of normal mode analysis for proteins with ‘non-interacting regions with PB change’

From: Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins

PDBcode

Region of interest

Mobile/Rigid?

Whole/Embedded

Mode

Cases with substantial change in non-interacting residues whereas interacting region has very less change

2HQS:A

Interface region

Highly mobile

Whole

5

 

NIR_PBc far away (mainly 86-91)

Highly mobile

Whole

3

1GHQ:A

Interface region

Highly mobile

Whole

1

 

NIR_PBc far away (264-274)

Partially mobile

Embedded

1

1OPH:A

Interface region

Highly mobile

Whole

1

 

NIR_PBc far away (120-123)

Mobile

Embedded

1

 

NIR_PBc near interface (191-194)

Mobile

Embedded

1

1KXP:D

Interface region

Rigid

-

-

 

NIR_PBc far away (314-325)

Low mobility

Embedded

1

 

NIR_PBc near interface (250-258)

Rigid

-

-

2BTF:A

Interface region

Rigid

-

-

 

NIR_PBc far away (156-158)

Rigid

-

-

1XD3:A

Interface region

Partly mobile

Embedded

2

 

NIR_PBc near interface (89-93)

Rigid

-

-

1BVK:F

Interface region

Partly mobile

Whole

1

 

NIR_PBc with interface (100-105)

Mobile

Embedded

2

1B6C:B

Interface region

Rigid

-

-

 

NIR_PBc near interface (15-22)

Mobile

Whole

3

 

NIR_PBc near interface (152-157)

Mobile

Embedded

4

Cases with substantial change in non-interacting residues near interacting region as well as in interacting region

1I2M:A

Interface region

Rigid

-

-

 

NIR_PBc far away (145-149)

Mobile

Embedded

4

 

NIR_PBc near interface (32-29)

Partly mobile

Embedded

2

  1. *The abbreviations used are: IR - Interface regions, NIR_PBc – Non-interacting regions with PB change.
  2. This table lists the results of the analysis using NMA regarding the intrinsic tendency for regions of interest to be rigid or mobile. The term ‘Embedded’ indicates that the region under consideration possesses intrinsic mobility as part of a segment, whereas the term ‘Whole’ indicates that the region is independent. NIR_PBc which are indicated to be mobile are shown in bold formatting and those indicated to be rigid are italicized. Note that the PDB codes and chains provided are for the bound form whereas the corresponding unbound form structure was used for NMA.