Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solution

Table 2 Intermolecular peptides sequences of BS ³ crosslinked peptides of Mo-MLV IN NTD and the Cβ distances between modified lysine residues (bold type) in the dimeric model

Crosslinking	Peptide 1	Peptide 2	Lysine involved	Distance (Å)
Intermolecular crosslinking	TVTDIKDLTK²⁴LGAIY	TK²⁴L	24 – 24 *	15.14
	LGAYDK³¹TK	MIENSSPYTSEHFHYTVTDIK²⁰DLTK²⁴LGAIYDK	31 – 20/24	20.02
	DK³¹TKKY	TVTDIK²⁰DLTKL	31 – 20 *	20.02
	MK⁶⁸ALLER	TLK⁸⁸NITETCK	68 – 88	13.57

ISSN: 1472-6807