Domain structure of the human MR. The N-terminal domain (NTD) is composed of two activatory domains (AF1a and AF1b) and the inhibitory domain (ID). This is followed by the DNA binding domain (DBD) and the ligand (sterol) binding domain (LBD). We found a region with tandem repeats that covers most of the ID starting at its N-terminal. Other isoforms of the human MR have been defined but their splicing does not affect the tandem repeat region . Isoform 1 is displayed (which is the longest one).