Figure 8

Similarities between crystal contacts observed in c5321 and in HcpC and interactions of Hop with the C-terminus of its Hsp70 target (PDB ID 1ELW). A. Structural superposition highlights similar mode of interaction involving concave region of the super-helix (molecule 1) and the extended peptide conformation of the C-terminus (molecule 2). B. Close-up of the hydrogen bonding interactions between the conserved asparagine residue (molecule 1, N310 in c5321) and the main chain of the C-terminus peptide (molecule 2). Note that the additional asparagine residue in c5321 (N345) is also involved in interactions with the main chain.