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Figure 4 | BMC Structural Biology

Figure 4

From: Disturbance of DNA conformation by the binding of testosterone-based platinum drugs via groove-face and intercalative interactions: a molecular dynamics simulation study

Figure 4

Groove widths and depths of B-DNA, Pt(Testo)(II) + DNA, Im-Pt(Testo)(II) + DNA and Pt(Py)(II) + DNA models. (a) The scheme of the minor and major groove widths/depths for the time-average structures of DNA conformations for the Pt(Testo)(II) + DNA adduct and B-DNA. (b) The major groove width; (c) the major groove depth; (d) the minor groove width; (e) the minor groove depth for the time-average structures of DNA conformations for the Pt(Testo)(II) + DNA adduct (red lines with circles), Im-Pt(Testo)(II) + DNA adduct (Magenta lines with down-triangles), Pt(Py)(II) + DNA adduct (blue lines with up-triangles) and B-DNA (black lines with square symbols) (black lines with squares).

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BMC Structural Biology

ISSN: 1472-6807

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