Disturbance of DNA conformation by the binding of testosterone-based platinum drugs via groove-face and intercalative interactions: a molecular dynamics simulation study

Table 2 Occupancies of hydrogen bonds between carbon hydrogen atoms of platinum agent (electron acceptor) and near bases on DNA (electron donor)

Adducts	Electron donor	Electron acceptor	Occupancy (%)
Pt(Testo)(II) + DNA	G28/O6	H-C_testosterone	20.82
	G15/O6	H-C_pyridyl	13.78
Im-Pt(Testo)(II) + DNA	T12/O2	H-C_testosterone	58.57
	A29/N3	H-C_testosterone	8.92
	G30/N3	H-C_testosterone	5.25

ISSN: 1472-6807