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Figure 7 | BMC Structural Biology

Figure 7

From: A structural role for the PHP domain in E. coli DNA polymerase III

Figure 7

Mutations at the PHP domain decrease Pol III polymerization activity. (A) Production of dsDNA was monitored by the intercalating dye PicoGreen. E. coli PHP mutants show substantially reduced polymerization activity. The decrease in activity correlates with the number of mutations introduced in the PHP domain. The relative polymerization rates of WT E. coli Pol III and the PHP mutants are shown in (B).

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