Figure 1

Reaction catalyzed by IspF. A catalytic Zn2+ aligns and polarizes the β-phosphate to support nucleophilic attack by the 2-phosphate to produce MEcPP and CMP.
Reaction catalyzed by IspF. A catalytic Zn2+ aligns and polarizes the β-phosphate to support nucleophilic attack by the 2-phosphate to produce MEcPP and CMP.