Figure 4

Superposition of the active site in Bc IspF and Pf IspF. Residues that bind CMP or CDP are displayed as sticks. Sequence numbers for Bc IspF are followed by those for Pf IspF, and residues contributed from the adjacent subunit are marked with’. Bc IspF and Pf IspF are colored cyan and green respectively. Key interactions are detailed in the text.