Figure 1

Structure of the heterodimer with a native interface. A) Structure of the heterodimer. Residues in the binding interface are shown in green. As shown schematically below the structure, each subunit bears a mutation in the surfaces needed to extend the polymer beyond a dimeric unit. The sites of the mutations are highlighted in red. B) A close up view of the native interface. Hydrophobic residues are colored green, negatively charged residues are in red and positively charged residues are in blue.