Figure 3

A structure-based multiple alignment of the DPBB domains from the β and β' subunits of DDRPs with a selection of other structurally characterized DPBB domains and the predicted DPBB domains of RDRP. The alignments were generated by structural superposition of representatives of the DPBB domains followed by addition of sequence neighbors. The predicted DPBB domain of the RDRPs was included on the basis of the alignment with the DDRP β' subunit's DPBB domain. The functionally important lysines in the β subunits and the metal-coordinating aspartates in the β' subunits are boxed. The conserved positions shared by the RDRPs with the structurally characterized DPBBs are indicated below the alignment by asterisks. The other conventions and abbreviations are as in the legends to Fig. 1 and Fig. 2.