From: Prediction of "hot spots" of aggregation in disease-linked polypeptides
Protein | Predicted "Hot Spots" | Experimental "Hot Spots" | Regions in the fibrils |
---|---|---|---|
Amyloid-β-protein | 16–21 | + | + |
 | 30–36 | + | + |
 | 38–42 | + | + |
Islet amyloid polypeptide | 12–18 | + | uncertain |
 | 22–28 | + | uncertain |
 | 1–18 | No experimental data available | uncertain |
α-Synuclein | 27–56 | + | uncertain |
 | 61–94 | + | + |
β2-Microgobulin | 21–31 | + | + |
 | 56–69 | + | + |
 | 79–85 | + | + |
 | 87–91 | + | + |
Lysozyme (hen) | 24–34 | - | - |
 | 50–62 | + | + |
 | 76–98 | + | + |
Transthyretin | 10–20 | + | + |
 | 23–33 | No experimetal data available | uncertain |
 | 105–118 | + | + |
Prion Protein | 1–32 | No experimetal data available | uncertain |
 | 105–146 | + | + |
 | 208–252 | No experimetal data available | uncertain |