Table 2 Repertoire of SAM-binding proteins in the Last Universal Common Ancestor
From: Natural history of S-adenosylmethionine-binding proteins
COG | Phyletic pattern parsimony1 | Tree topology2 | Protein product name and function | Fold class |
|---|---|---|---|---|
|  |  |  | SAM-binding proteins in LUCA – best-supported COGs | |
COG0030 | 1/0 | + | KsgA, Dimethyladenosine transferase (rRNA methylation) | Rossmann fold |
COG0144 | 1/0 | + | Sun, tRNA and rRNA cytosine-C5-methylases | Rossmann fold |
COG0192 | 0/1 3 | + 3 | MetK, S-adenosylmethionine synthetase (releases SAM as product) | SAM synthase |
COG0421 | 1/0 | + | SpeE, Spermidine synthase | Rossmann fold |
COG0500 | 1/0 | + | SmtA, SAM-dependent methyltransferases | Rossmann fold |
COG0621 | 1/0 | + | MiaB, 2-methylthioadenine synthetase | Rossmann fold |
COG1180 | 0/1 | + | PflA, Pyruvate-formate lyase-activating enzyme | SAM radical (TIM barrel) |
COG1586 | 0/1 3 | + 3 | SpeD, S-adenosylmethionine decarboxylase | SAM decarboxylase |
COG2890 | 1/0 | + | PrmC (HemK), Methylase of polypeptide chain release factors | Rossmann fold |
|  |  |  | SAM-binding proteins in LUCA – tentatively supported COGs | |
COG0007 | 1/0 | ? | CysG, Uroporphyrinogen-III methylase | SAM radical (TIM barrel) |
COG0220 | 1/0 | ? | Predicted S-adenosylmethionine-dependent methyltransferase | Rossmann fold |
COG0293 | 0/1 | ? | FtsJ, 23S rRNA methylase | Rossmann fold |
COG0320 | 0/1 | ? | LipA, Lipoate synthase | SAM radical (TIM barrel) |
COG0502 | 0/1 | ? | BioB, Biotin synthase and related enzymes | SAM radical (TIM barrel) |
COG0565 | 0/1 | ? | LasT, rRNA methylases | SPOUT |
COG0685 | 1/0 | ? | MetF, 5,10-methylenetetrahydrofolate reductase (binds SAM as inhibitor) | TIM barrel |
COG1189 | 0/1 | ? | Predicted rRNA methylase | Rossmann fold |
COG2226 | 1/0 | ? | UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis | Rossmann fold |