Figure 6

Prediction of lipid-exposed and buried faces in TRPV1 TM helices. (A) TM region of the rat brain K⁺ channel (PDB: 2A79), which is used here as a structural model for TRPV1 channel. A monomer is shown in thick orange-and-yellow ribbons, while a helical part of the re-entrant loop is shown in green. B) K⁺ channel monomer with helical wheel cartoons showing predicted lipid-exposed (outlined with orange) and buried (outlined with green) faces of TRPV1 channel. The residues forming buried and exposed faces are listed on Table 3.