Figure 8
From: Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy
Pressure effects on hu PrP(121–230). (a) Ribbon and CPK representations of the NMR structure of hu PrP(121–230) (taken from PDB 1QM2) with molecular cavities added (dark spheres) defined by a probe radius of 0.12 nm. Residues showing no significant changes of the cross peak volumes are colored dark blue. Residues associated with ΔG0values characteristic for the N → I transition from group one (lower ΔG0) are depicted in red, from group two (higher ΔG0) orange. Regions where the signal volume could not be determined are colored light blue, residues not visible or assigned grey. (b) Same as (a) rotated by 180° around the y-axis. (c) Same as (a) rotated by 90° around the x-axis. Figure was prepared using MOLMOL [60].