Figure 9
From: Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy
Schematic view of the free energy landscape of the human prion protein as a function of pressure. The molar free energy differences ΔGi = Gi(p)-GN(p) of the four main conformations N1, N2 and I1 and I2 are depicted as function of the pressure p at constant temperature T of 293 K. In this representation as ground state N the state N1 was assumed (but see discussion). Note that the abscissa represents a generalized coordinate in the conformational space that only schematically depicts the conformational states.