Skip to main content
Figure 2 | BMC Structural Biology

Figure 2

From: Autoinsertion of soluble oligomers of Alzheimer's Aβ(1–42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface

Figure 2

Calculation of bilayer scattering length density profiles from neutron diffraction data. Panel a shows structure factors obtained from POPC/Chol (70:30 mol%) membranes, and fitting to a continuous transform for phase determination (- - + - + for orders #1–5 in this example). The data points (open circles) include measurements at up to 3 different relative humidities (i.e. 3 different lamellar spacings). Panel b shows the scattering length density (SLD) profile calculated by Fourier synthesis using the signed form factors obtained in part a, after scaling the data to match the mean scattering length of the bilayer unit cell. The main features of the centrosymmetric profile, corresponding to the space-filling model of POPC, are described in detail in the text.

Back to article page

BMC Structural Biology

ISSN: 1472-6807

Contact us