Figure 3

N-SH2 average structures from molecular dynamics simulations. Red: the 5–10 ns interval of the simulation of N-SH2 as started from the isolated N-SH2 crystal coordinates (1AYD:N-SH2:5–10 ns); Orange: the 5–10 ns interval of the simulation of N-SH2 as started from the full SHP-2 crystal coordinates (2SHP:N-SH2:5–10 ns); Yellow: the 3–5 ns interval of the simulation of the full SHP-2 protein (2SHP:SHP-2:3–5 ns).