Table 3 Predicted penetration depths (D) and binding energies (ΔG calc ) of peripheral proteins, whose orientations with respect to the membrane have been previously suggested based on their 3D structures
From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes
Protein | PDB id | ΔG calc (kcal/mol) | D(Å) | References |
|---|---|---|---|---|
Lipid clamps | ||||
GRK2 kinase -βγ complex | 2bcj | -5.5 | 5.0 | [131] |
Seminal plasma protein | 1h8p | -12.3 | 9.2 | [132] |
Myotubularin-related protein | 1zvr | -2.3 | 2.9 | [133] |
Other proteins | ||||
Fatty acid amine hydrolase | 1mt5 | -30.8 | 10.0 | [134] |
Signal peptidase | 1kn9 | -4.5 | 4.5 | [135] |
Lanosterol synthase | 1w6k | -19.9 | 6.5 | [136] |
Monoamine oxidase | 1o5w | -19.9 | 6.5 | [137] |
Prostaglandin E synthase | 1z9h | -13.1 | 4.4 | [49] |
Carnitine O-palmitoyltransferase 2 | 2h4t | -8.3 | 3.6 | [138] |
Major envelope glycoprotein E | 1ok8 | -9.9 | 4.9 | [139] |
Ferrochelatase | 1hrk | -9.2 | 7.2 | [140] |
Sphingomyelinase C | 1zwx | -6.2 | 6.0 | [141] |
α-Toxin (bacterial phospholipase C) | 1olp | -4.8 | 3.3 | [142] |
β-glycosidase | 1vff | -6.5 | 3.3 | [143] |
Hydroxysteroid dehydrogenase | 1y5m | -14.9 | 3.0 | [144] |
Carotenoid oxygenase | 2biw | -12.7 | 5.1 | [145] |
α-Tocopherol transfer protein | 1oiz | -20.7 | 8.4 | [146] |
Phosphatidylinositol transfer protein | 1aua | -14.0 | 7.8 | [147] |
Ganglioside GM2 activator | 1pub | -7.8 | 5.2 | [148] |
Oxysterol-binding protein | 1zi7 | -5.9 | 3.0 | [149] |
Viscotoxin A3 | 1okh | -4.0 | 5.8 | [150] |