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Table 5 Typical membrane binding elements, calculated energies (ΔG calc , kcal/mol) and membrane penetration depths (D, Å) for different categories of membrane-associated proteins (see Additional file 1)

From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Category Na Binding elements ΔG calc (kcal/mol) D
A. Extramembrane domains of transmembrane proteins 29 α-helices, loops -2.4 to -30.8 2.3 to 12.5
B. Integral monotopic 6 α helices, -8.6 to -38.3 4 to 10
C.1. Peripheral enzymes 119 α-helices, loops -1.4 to -38.2 1 to 13
C.2. Water-soluble carriers of non-polar substances 42 α-helices, loops, β-sheets -2.2 to -20.7 2 to 8
C.3. Membrane-targeting and other structural domains 93 loops, α-helices, bound lipids -1.2 to -12.3 1 to 9
C.4. Electron carriers 24 Loops -1.2 to -7.5 1 to 5
C.5. Polypeptide ligands (hormones, toxins, inhibitors) 101 β-sheets, α-helices, loops -1.6 to -18.1 1 to 18
C.6. Water-soluble forms of channel-forming polypeptides 38 α-helices, loops -1.3 to -20.9 1 to 28
  1. aNumber of different protein structures in the set.
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