Table 6 Calculated parameters of open and closed states of membrane-associated proteins: binding energies (ΔG calc , kcal/mol), penetration depths (D, Å), and tilt angles (τ, °).
From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes
Protein | Category | "Closed" state | "Open"/lipid-bound state | ||||||
|---|---|---|---|---|---|---|---|---|---|
|  |  | PDB id | Δ G calc | D | τ | PDB id | Δ G calc | D | τ |
Cytochrome P450 2b4 | A.1 | 1suo | -13.0 | 4.7 | 54 | 2bdm | -18.2 | 10.5 | 45 |
Fungal lipase 1 | C.1 | 1trh | -7.8 | 3.0 | 80 | 1lpp | -30.6 | 9.1 | 84 |
Triacylglycerol lipase Rhizomucor miehei | C.1 | 3tgl | -4.1 | 4.5 | 28 | 4tgl | -14.0 | 4.9 | 55 |
Triacylglycerol lipase Humicola lanuginose | C.1 | 1tib | -3.3 | 1.9 | 42 | 1ein | -13.5 | 9.5 | 71 |
Gastric lipasea | C.1 | 1hlg | -5.0 | 3.4 | 6 | 1k8q | -10.8 | 6.3 | 80 |
α-Toxin (Phospholipase C) | C.1 | 1gyg | -4.2 | 5.5 | 60 | 1ca1 | -4.5 | 2.2 | 88 |
Alpha-tocopherol transfer protein | C.2 | 1r5l | -10.6 | 4.0 | 81 | 1oiz | -20.7 | 8.4 | 63 |
Glycolipid transfer protein | C.2 | 1swx | -4.9 | 3.4 | 86 | 1sx6 | -7.9 | 3.9 | 87 |
Ganglioside GM2 activator | C.2 | 2ag4 | -5.1 | 4.2 | 47 | 1tjj | -9.3 | 4.6 | 55 |
Synaptotagmin C2A domain of b | C.4 | 1rsy | -3.3 | 2.1 | 26 | 1bync | -4.4 | 3.7 | 36 |
Mersacidind | C.7 | 1mqxc | -2.3 | 2.4 | 77 | 1mqyc | -9.5 | 11.5 | 56 |