Spectrum of disease-causing mutations in protein secondary structures

BMC Structural Biology

Table 10 Spectrum of mutations in β-strands in amino acid groups^a

Amino acid group	Original residues	Expected residues	χ²	P value	Mutant residues	Expected residues	χ²	P value
Hydrophobic	241	285	6.72**	9.54E-03	170	191	2.27	1.32E-01
Positively charged	38	40	0.12	7.31E-01	46	42	0.36	5.47E-01
Negatively charged	113	65	35.48***	2.58E-09	115	90	7.07**	7.82E-03
Conformational	59	39	10.86***	9.81E-04	74	66	0.98	3.21E-01
Polar	44	53	1.62	2.03E-01	95	94	0.01	9.18E-01
A+T	55	68	2.58	1.08E-01	50	67	4.47*	3.45E-02
Sum	550	550			550	550

^aχ²-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ² are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

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