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Table 10 Spectrum of mutations in β-strands in amino acid groupsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid group Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
Hydrophobic 241 285 6.72** 9.54E-03 170 191 2.27 1.32E-01
Positively charged 38 40 0.12 7.31E-01 46 42 0.36 5.47E-01
Negatively charged 113 65 35.48*** 2.58E-09 115 90 7.07** 7.82E-03
Conformational 59 39 10.86*** 9.81E-04 74 66 0.98 3.21E-01
Polar 44 53 1.62 2.03E-01 95 94 0.01 9.18E-01
A+T 55 68 2.58 1.08E-01 50 67 4.47* 3.45E-02
Sum 550 550    550 550   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.