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Figure 6 | BMC Structural Biology

Figure 6

From: Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails

Figure 6

NMR titrations of Brd2 BD2 with mutated histone H4 tails. Brd2 BD2 was titrated with different H4-AcK12 peptide mutants, including H4-L10A, H4-L10G, H4-A15G, H4-acid and the unacetylated peptide H4-U. Combined chemical shift perturbation was calculated using the equation, Δ δ p p m = ( Δ δ H N ) 2 + ( Δ δ N α N ) 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqHuoariiGacqWF0oazdaWgaaWcbaGaemiCaaNaemiCaaNaemyBa0gabeaakiabg2da9maakaaabaGaeiikaGIaeuiLdqKae8hTdq2aaSbaaSqaaiabdIeaijabd6eaobqabaGccqGGPaqkdaahaaWcbeqaaiabikdaYaaakiabgUcaRiabcIcaOiabfs5aejab=r7aKnaaBaaaleaacqWGobGtaeqaaOGae8xSde2aaSbaaSqaaiabd6eaobqabaGccqGGPaqkdaahaaWcbeqaaiabikdaYaaaaeqaaaaa@489D@ , and R = [peptide]/[bromodomain].

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