Figure 3

Comparison of different HGPRT structures in the region surrounding the cis peptide bond. (A) Superposed structures of HGPRT from L. tarentolae in gray (PDB 1PZM), T. gondii in purple (PDB 1QK5), human in magenta (PDB 1BZY), T. cruzi in green (DB 1TC2), E. coli in blue light (PDB), P. falciparum in blue dark (PDB 1CJB), S. typhimurium in orange (PDB 1J7J) and T. tengcongensis in yellow (PDB 1YFZ). The network of saline bridges is shown. (B) Comparison of different human HGPRT structures: the ImmGP-PPi-Mg complex in magenta (PDB 1BZY), which has a cis conformation, is superposed to the apoenzyme in blue (PDB 1Z7G) and the GMP complex in salmon (PDB 1HMP), which have a trans conformation.