Figure 4From: Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferaseL. tarentolae HGPRT with bound GMP superposed on the human homologue. H-bonds are shown as dotted lines. (A) Active site interactions of human (green) and Leishmania (blue) HGPRT with guanine. A purine base displacement is visible. (B) Interactions of phosphate group and ribose in the C3'-endo conformation. The arrows show differences in the arrangement of ribose carbon C5*.Back to article page