Table 3 IC50 values of purine and pyrimidine analogs for Leishmania HGPRT
From: Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase
Inhibitor | IC50 (μM) |
|---|---|
8-aminoguanosine | 94 |
cefotaxime | 180 |
allopurinol | 194 |
azaadenine | 210 |
formicin B | 260 |
caffeine | 336 |
5-bromodeoxiuridine | 350 |
5-metilcitosine | 412 |
Orotic acid | 432 |
tubercidine | 533 |
6-cloroguanine | 838 |