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Figure 1 | BMC Structural Biology

Figure 1

From: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

Figure 1

Ternary ligand-receptor complex of wildtype BMP-2. Ribbon representation (stereo figure) of the crystal structure of wildtype BMP-2 (monomers in yellow and blue) bound to one receptor ectodomain of BMPR-IAECD (green) and ActR-IIBECD (red), (a) viewed from the side, (b) or from above. The unexpected stoichiometry 1:1:1 is due to crystal packing forces resulting in the loss of one BMPR-IAECD and one ActR-IIBECD molecule in the ternary complex.

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BMC Structural Biology

ISSN: 1472-6807

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