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Figure 4 | BMC Structural Biology

Figure 4

From: The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor

Figure 4

Identification of additional determinants in TAS1R3 critical for responsiveness to cyclamate and lactisole. (A) Concentration-dependent inhibition of calcium responses to 10 mM aspartame by lactisole in HEK293T-G16Gust44 cells cotransfected with DNA for wild type hTAS1R2/hTAS1R3 (filled circle, solid line), C801I7.39 (open diamond, short dashed line), Y699L5.60 (open circle, dash-dot-dotted line), Y699F5.60 (filled triangle up, medium dashed line), or W775A6.48 (filled hexagon, dash-dotted line) and hTAS1R2 DNA. (B) Concentration-dependent responses of HEK293T-G16Gust44 cells to cyclamate cotransfected with DNA for hTAS1R3 (filled circle, solid line), S726A5.39 (open triangle up, medium dashed line), C801I7.39 (open diamond, short dashed line), or W775A6.48 (filled hexagon, dash-dotted line) and hTAS1R2.

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