Figure 4
From: Neutral evolution of Protein-protein interactions: a computational study using simple models
Absence of correlation of n and T f with dimerization ability. A) For a representative 2D protein dimer, we show the mutational robustness n of each viable sequence pair, versus the cellular concentration [AB]func of the functional dimer at chemical equilibrium for that pair. No selective pressure for dimerization is applied. The black line represents the average over the distribution of n values for each value of [AB]func. n and [AB]func are seen to be uncorrelated. B) For the same 2D dimer, we show the folding temperature of each viable sequence pair as a function of [AB]func. C) For the Grb2-Vav 3D dimer, we show the Z value (which measures the dimerization ability) of each viable sequence pair as a function of n. The two are seen to be uncorrelated, even though a selective pressure for dimerization is present in this case (see text).