Figure 7
From: Neutral evolution of Protein-protein interactions: a computational study using simple models
Emergence of a "functional funnel" in sequence space. A) 2D dimer: The mean concentration [AB]func of the functional dimer as a function of the distance of each viable sequence pair from the prototype pair (the most populated pair in the steady state). Data are shown for a representative dimer and a selection threshold of δ = 0.08 (dotted horizontal line). There are no sequence pairs below the dotted line, because such sequences are not viable, by definition. Black curve: the mean value for each distance. Black vertical bars indicate the standard deviation at each distance. Dashed horizontal line: average over a random set of sequences. Solid horizontal line: overall steady state average. The concentration [AB]func varies widely, but the mean value drops off rapidly and smoothly as one moves away from the prototype sequence pair. B) Similar representation for the 3D Grb2-Vav dimer: the dimerization Z score as a function of the distance from the prototype sequence.